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Our White Sox vs. Guardians prediction and picks for the ALDS Game 1 on Saturday, October 3 are headlined by Miguel Vargas and Parker Messick on PrizePicks.
Get real-time MLB coverage and scores as the Chicago White Sox take on the Cleveland Guardians at 5:00pm EDT on October 05, 2026. The Athletic brings you the latest stats, scores, and analysis of your favorite teams.
In just two years, the White Sox have jumped from a record-setting 121 losses to winning their first playoff series in 21 years.