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Oregon vs. USC Predictions: Week 4 Odds, Picks & Best Bets
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- Sep 26, 2026, 7:33 PM UTC
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Week 4 college football picks for Oregon vs. USC, with the latest odds, spread and total analysis, plus player prop picks for this projected Big Ten shootout in L.A.
USC and Oregon have plenty of questions to answer in Week 4.
Our Oregon vs. USC prediction and picks for Saturday project a high-scoring shootout between the Ducks and Trojans.