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San Francisco enters this NFC West matchup having outscored opponents 62-20 across two wins, and the machinery behind that production is humming. Brock
The Arizona Cardinals continue an early-season stretch heavy on road games when they visit the San Francisco 49ers at Levi's Stadium for an NFC West matchup on Sunday afternoon. Sep 20, 2026; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) celebrates with quarterback Brock Purdy…
Find Cardinals vs 49ers predictions, picks, and odds for NFL Week 3 on Sunday, Sept. 27.