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Professional American football league
The National Football League (NFL) is a professional American football league in the United States. Composed of 32 teams, it is divided equally between the American Football Conference (AFC) and the National Football Conference (NFC). The NFL is one of the major professional sports leagues in the United States and Canada and the highest professional level of American football in the world.
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The Arizona Cardinals continue an early-season stretch heavy on road games when they visit the San Francisco 49ers at Levi’s Stadium for an NFC West matchup on Sunday afternoon. How to Watch Cardinals vs 49ers Arizona is playing its second…
Watch Cardinals vs 49ers live from Levi's Stadium in CA on Sun, Sept. 27, 2026 at 4:05 p.m. ET / 1:05 p.m. PT. Stream NFL on FOX One. Start your 3-day free trial.
Learn which TV channel or how to live stream the NFL Week 3 Arizona Cardinals and San Francisco 49ers game.