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10 Best College Football Picks Against the Spread for Week 4
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- Sep 25, 2026, 9:40 AM UTC
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Our Week 4 college football against the spread picks expect Oregon to snag a big win, and LSU to bounce back in a big way.
This week's slate is full of intrigue as conference play blossoms into full bloom. Can Indiana cover a massive spread vs. lowly Rutgers? Can Florida stay perfect with a win over Mizzou?
No. 1 Texas makes its first road trip to Tennessee, while Oregon visits unbeaten USC and Missouri faces No. 24 Mississippi State in Starkville.